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          Institute: MPI für medizinische Forschung     Collection: Max-Planck-Forschungsgruppe Ionenkanalstruktur (Dean R. Madden)     Display Documents



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ID: 23092.0, MPI für medizinische Forschung / Max-Planck-Forschungsgruppe Ionenkanalstruktur (Dean R. Madden)
The inner workings of AMPA receptors
Translation of Title:The inner workings of AMPA receptors
Authors:Madden, Dean R.
Language:English
Date of Publication (YYYY-MM-DD):2002
Title of Journal:Current Opinion in Drug Discovery Development
Journal Abbrev.:Curr. Opin. Drug Disc. Dev.
Volume:5
Issue / Number:5
Start Page:741
End Page:748
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:As with all ligand-gated ion channels, ionotropic glutamate receptors (iGluRs) convert the free energy of agonist-binding into a sequence of conformational changes that allow regulated ion flux across an otherwise insulating membrane bilayer. In the case of iGluRs, the resulting membrane depolarization is a key mediator of intercellular signals in the synapses of the CNS. Recent biomedical and structural research has greatly expanded our understanding of the chemistry of iGluR agonist binding, and of the subsequent molecular changes that drive channel gating and desensitization.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Nachwuchsgruppe Ion Channel Structure
Identifiers:URI:http://www.biomedcentral.com/pubmed/12630294 [Abstract]
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