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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 23219.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo
Translation of Title:Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo
Authors:Sprengel, Rolf; Suchanek, Bettina; Amico, Carla; Brusa, Rossella; Burnashev, Nail; Rozov, Andrej; Hvalby, Øivind; Jensen, Vidar; Paulsen, Ole; Andersen, Per; Kim, Jin-Hyun; Thompson, Richard F.; Sun, William; Webster, Lorna C.; Grant, Seth G. N.; Eilers, Jens; Konnerth, Arthur; McNamara, James O.; Seeburg, Peter H.
Language:English
Date of Publication (YYYY-MM-DD):1998-01-23
Title of Journal:Cell
Journal Abbrev.:Cell
Volume:92
Start Page:279
End Page:289
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice expressing NMDA receptors without the large intracellular C-terminal domain of any one of three NR2 subunits phenotypically resemble mice made deficient in that particular subunit. Mice expressing the NR2B subunit in a C-terminally truncated form (NR2BΔC/ΔC mice) die perinatally. NR2AΔC/ΔC mice are viable but exhibit impaired synaptic plasticity and contextual memory. These and NR2CΔC/ΔC mice display deficits in motor coordination. C-terminal truncation of NR2 subunits does not interfere with the formation of gateable receptor channels that can be synaptically activated. Thus, the phenotypes of our mutants appear to reflect defective intracellular signaling.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.cell.com/content/article/fulltext?uid=P... [Full text]
URI:http://www.cell.com/content/article/abstract?uid=P... [Abstract]
URI:http://download.cell.com/pdfs/0092-8674/PIIS009286... [Fulltext PDF]
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