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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents

ID: 23268.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice
Translation of Title:Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice
Authors:Hormuzdi, Sheriar G.; Pais, Isabel; LeBeau, Fiona E.N.; Towers, Stephen K.; Rozov, Andrej; Buhl, Eberhard H.; Whittington, Miles A.; Monyer, Hannah
Date of Publication (YYYY-MM-DD):2001-08-16
Title of Journal:Neuron
Journal Abbrev.:Neuron
Start Page:487
End Page:495
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Neural processing occurs in parallel in distant cortical areas even for simple perceptual tasks. Associated cognitive binding is believed to occur through the interareal synchronization of rhythmic activity in the ? (30?80 Hz) range. Such oscillations arise as an emergent property of the neuronal network and require conventional chemical neurotransmission. To test the potential role of gap junction-mediated electrical signaling in this network property, we generated mice lacking connexin 36, the major neuronal connexin. Here we show that the loss of this protein disrupts ? frequency network oscillations in vitro but leaves high frequency (150 Hz) rhythms, which may involve gap junctions between principal cells (Schmitz et al., 2001), unaffected. Thus, specific connexins differentially deployed throughout cortical networks are likely to regulate different functional aspects of neuronal information processing in the mature brain.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.neuron.org/content/article/fulltext?uid... [Full text]
URI:http://www.neuron.org/cgi/content/abstract/31/3/48... [Abstract]
URI:http://download.neuron.org/pdfs/0896-6273/PIIS0896... [Fulltext PDF]
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