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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 23271.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice
Translation of Title:Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice
Authors:Mack, Volker; Burnashev, Nail; Kaiser, Katharina M. M.; Rozov, Andrej; Jensen, Vidar; Hvalby, Øivind; Seeburg, Peter H.; Sakmann, Bert; Sprengel, Rolf
Language:English
Date of Publication (YYYY-MM-DD):2001-06-29
Title of Journal:Science
Journal Abbrev.:Science
Volume:292
Issue / Number:5526
Start Page:2501
End Page:2504
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A-/- mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP.
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.sciencemag.org/cgi/content/full/292/552... [Full text]
URI:http://www.sciencemag.org/cgi/content/abstract/292... [Abstract]
URI:http://www.sciencemag.org/cgi/reprint/292/5526/250... [Fulltext PDF]
DOI:10.1126/science.1059365
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