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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 23273.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
AMPA receptor channels with long-lasting desensitization in bipolar interneurons contribute to synaptic depression in a novel feedback circuit in layer 2/3 of rat neocortex
Translation of Title:AMPA receptor channels with long-lasting desensitization in bipolar interneurons contribute to synaptic depression in a novel feedback circuit in layer 2/3 of rat neocortex
Authors:Rozov, Andrej; Jerecic, Jasna; Sakmann, Bert; Burnashev, Nail
Language:English
Date of Publication (YYYY-MM-DD):2001-10-15
Title of Journal:Journal of Neuroscience
Journal Abbrev.:J. Neurosci.
Volume:21
Issue / Number:20
Start Page:8062
End Page:8071
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:A novel, local inhibitory circuit in layer 2/3 of rat somatosensory cortex is described that connects pyramidal cells reciprocally with GABAergic vasoactive intestinal polypeptide-immunoreactive bipolar interneurons. In paired whole-cell recordings, the glutamatergic unitary responses (EPSPs or EPSCs) in bipolar cells evoked by repetitive (10 Hz) stimulation of a pyramidal cell show strong frequency-dependent depression. Unitary IPSPs evoked in pyramidal cells by repetitive stimulation of bipolar cells, on average, maintained their amplitude. This suggests that the excitatory synapses on bipolar cells act as a low-pass filter in the reciprocal pyramid-to-bipolar circuit. The EPSCs in bipolar cells are mediated predominantly by AMPA receptor (AMPAR) channels. AMPARs desensitize rapidly and recover slowly from desensitization evoked by a brief pulse of glutamate. In slices, reduction of AMPAR desensitization by cyclothiazide (50-100 ?M) or conditioning steady-state desensitization induced by application of extracellular AMPA (50 nM) or glutamate (50 ?M) strongly reduced synaptic depression. It is concluded that in the local circuits between pyramidal and bipolar cells the desensitization of AMPARs in bipolar cells contributes to low-pass feedback inhibition of layer 2/3 pyramidal neurons by bipolar cells.
Free Keywords:neocortex; interneurons; neuronal circuit; synaptic depression; AMPA receptors; desensitization
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Zellphysiologie/
MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie/
Identifiers:URI:http://www.jneurosci.org/cgi/content/full/21/20/80... [Full text]
URI:http://www.jneurosci.org/cgi/content/abstract/21/2... [Abstract]
URI:http://www.jneurosci.org/cgi/reprint/21/20/8062htt... [Fulltext PDF]
ISSN:0270-6474/01/21208062-10$05.00/0
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