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          Institute: MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut)     Collection: Publikationen des W. G. Kerckhoff-Instituts     Display Documents



ID: 233667.0, MPI für Herz- und Lungenforschung (W. G. Kerckhoff Institut) / Publikationen des W. G. Kerckhoff-Instituts
Matrix metalloproteinases and their tissue inhibitors in pressure-overloaded human myocardium during heart failure progression
Authors:Polyakova, V.; Hein, S.; Kostin, S.; Ziegelhoeffer, T.; Schaper, J.
Date of Publication (YYYY-MM-DD):2004-10-19
Journal Abbrev.:J Am Coll Cardiol
Volume:44
Issue / Number:8
Start Page:1609
End Page:1618
Audience:Not Specified
Abstract / Description:OBJECTIVES: We studied the role of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in fibrosis formation in the transition from hypertrophy to heart failure (HF) as well as the cellular source of MMPs and TIMPs. BACKGROUND: Human pressure-overloaded hearts are characterized
Free Keywords:Aged ; Aortic Valve Stenosis/*pathology/surgery ; Biopsy ; Cell Division/physiology ; Disease Progression ; Endocardium/pathology ; Endomyocardial Fibrosis/*pathology ; Extracellular Matrix/pathology ; Female ; Fibroblasts/pathology ; Heart Failure, Congestive/*pathology ; Heart Valve Prosthesis Implantation ; Humans ; Hypertrophy, Left Ventricular/*pathology ; Male ; Matrix Metalloproteinases/*metabolism ; Microscopy, Fluorescence ; Middle Aged ; Myocardium/pathology ; Protein Isoforms/*metabolism ; Reference Values ; Research Support, Non-U.S. Gov't ; Tissue Inhibitor of Metalloproteinases/*metabolism ; Ventricular Remodeling/physiology
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für physiologische und klinische Forschung
Identifiers:URL:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=...
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