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          Institute: MPI für Evolutionsbiologie     Collection: Evolutionary ecology     Display Documents

ID: 233932.0, MPI für Evolutionsbiologie / Evolutionary ecology
Rapid evolution of the MH class I locus results in different allelic compositions in recently diverged populations of Atlantic salmon
Authors:Consuegra, S.; Megens, H.-J.; Schaschl, H.; Leon, K.; Stet, R. J. M.; Jordan, W. C.
Date of Publication (YYYY-MM-DD):2005-04
Title of Journal:Molecular Biology and Evolution
Journal Abbrev.:Mol. Biol. Evol.
Issue / Number:4
Start Page:1095
End Page:1106
Review Status:not specified
Audience:Not Specified
Abstract / Description:We compared major histocompatibility class I allelic diversity in two currently reproductively isolated Atlantic salmon (Salmo salar) populations (Irish and Norwegian) with a common postglacial origin in order to test for among-population differences in allelic composition and patterns of recombination and point mutation. We also examined the evidence for adaptive molecular divergence at this locus by analyzing the rate of amino acid replacement in relation to a neutral expectation. Contrary to our prediction, and in contrast to the situation for other genetic markers, the two populations have almost nonoverlapping sets of major histocompatibility class I alleles. Although there is a strong signal of point mutation that predates population divergence, recent recombination, acting in similar, but not identical, ways in both populations appears to be a significant force in creating new alleles. Moreover, selection acting on peptide-binding residues seems to favor new recombinant alleles and is likely to be responsible for the rapid divergence between populations.
Free Keywords:MHC; recombination; positive selection; Atlantic salmon; Salmo salar
External Publication Status:published
Document Type:Article
Affiliations:MPI für Limnologie/Abt. Evolutionsökologie
External Affiliations:Univ St Andrews, Gatty Marine Lab, Fish Muscle Res Grp, St Andrews, Fife Scotland; Zool Soc London, Inst Zool, London, NW1 4RY England; Wageningen Univ, Dept Anim Sci, Cell Biol & Immunol Grp, Wageningen, Netherlands
Identifiers:ISSN:0737-4038 [ID-No:1]
DOI:10.1093/molbev/msi096 [ID-No:2]
LOCALID:2369/S 38393 [Listen-Nummer/S-Nummer]
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