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          Institute: MPI für molekulare Genetik     Collection: Department of Human Molecular Genetics     Display Documents

ID: 24159.0, MPI für molekulare Genetik / Department of Human Molecular Genetics
Four-Hundred Million Years of Conserved Synteny of Human Xp and Xq Genes on Three Tetraodon Chromosomes
Authors:Grützner, Frank; Roest Crollius, Hugues; Lütjens, Götz; Jaillon, Olivier; Weissenbach, Jean; Ropers, Hans Hilger; Haaf, Thomas
Date of Publication (YYYY-MM-DD):2002-08-21
Title of Journal:Genome Research
Issue / Number:9
Start Page:1316
End Page:1322
Review Status:not specified
Audience:Experts Only
Abstract / Description:The freshwater pufferfish Tetraodon nigroviridis (TNI) has become highly attractive as a compact reference vertebrate genome for gene finding and validation. We have mapped genes, which are more or less evenly spaced on the human chromosomes 9 and X, on Tetraodon chromosomes using fluorescence in situ hybridization (FISH), to establish syntenic relationships between Tetraodon and other key vertebrate genomes. PufferFISH revealed that the human X is an orthologous mosaic of three Tetraodon chromosomes. More than 350 million years ago, an ancestral vertebrate autosome shared orthologous Xp and Xq genes with Tetraodon chromosomes 1 and 7. The shuffled order of Xp and Xq orthologs on their syntenic Tetraodon chromosomes can be explained by the prevalence of evolutionary inversions. The Tetraodon 2 orthologous genes are clustered in human Xp11 and represent a recent addition to the eutherian X sex chromosome. The human chromosome 9 and the avian Z sex chromosome show a much lower degree of synteny conservation in the pufferfish than the human X chromosome. We propose that a special selection process during vertebrate evolution has shaped a highly conserved array(s) of X-linked genes long before the X was used as a mammalian sex chromosome and many X chromosomal genes were recruited for reproduction and/or the development of cognitive abilities.
External Publication Status:published
Document Type:Article
Communicated by:Hans-Hilger Ropers
Affiliations:MPI für molekulare Genetik
External Affiliations:Comparative Genomics Group, Research School of Biological Sciences, Australian National University, Canberra, ACT 2601, Australia
Genoscope, CNRS UMR8030, 91057 Evry Cedex, France
Institute of Human Genetics, Mainz University School of Medicine, 55101 Mainz, Germany
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