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          Institute: MPI für molekulare Pflanzenphysiologie     Collection: Publikationen Pflanzenphysiologie     Display Documents

ID: 251075.0, MPI für molekulare Pflanzenphysiologie / Publikationen Pflanzenphysiologie
Computational methods for the design of effective therapies against drug resistant HIV strains
Authors:Beerenwinkel, N.; Sing, T.; Lengauer, T.; Rahnenfuhrer, J.; Roomp, K.; Savenkov, I.; Fischer, R.; Hoffmann, D.; Selbig, J.; Korn, K.; Walter, H.; Berg, T.; Braun, P.; Fatkenheuer, G.; Oette, M.; Rockstroh, J.; Kupfer, B.; Kaiser, R.; Daumer, M.
Date of Publication (YYYY-MM-DD):2005-11-01
Title of Journal:Bioinformatics
Journal Abbrev.:Bioinformatics
Issue / Number:21
Start Page:3943
End Page:3950
Review Status:not specified
Audience:Not Specified
Abstract / Description:The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data.
Free Keywords:immunodeficiency-virus type-1
; susceptibility phenotype
; evolutionary pathways
; reverse-transcriptase
; neural-networks
; genotype
; prediction
; geno2pheno
; protease
; models
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Pflanzenphysiologie/Zentrale Infrastrukturgruppen/AG Selbig
External Affiliations:Univ Calif Berkeley, Dept Math, Berkeley, CA 94720 USA
Univ Calif Berkeley, Dept Math, Berkeley, CA 94720 USA
Max Planck Inst Informat, Saarbrucken, Germany
Ctr Adv European Studies & Res, Bonn, Germany
Max Planck Inst Mol Physiol, D-44139 Dortmund, Germany
Univ Potsdam, Potsdam, Germany
Univ Erlangen Nurnberg, Inst Clin & Mol Virol, Erlangen, Germany
Med Lab, Berlin, Germany
PZB, Aachen, Germany
Univ Cologne, Dept Internal Med, Cologne, Germany
Univ Cologne, Inst Virol, Cologne, Germany
Univ Dusseldorf, Dept Gastroenterol, D-4000 Dusseldorf, Germany
Univ Bonn, Dept Internal Med, D-5300 Bonn, Germany
Univ Bonn, Inst Med Microbiol & Immunol, D-5300 Bonn, Germany
Identifiers:ISI:000232901100001 [ID No:1]
ISI:000232901100001 [ID No:2]
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