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          Institute: MPI für evolutionäre Anthropologie     Collection: Publications MPI for Evolutionary Anthropology     Display Documents



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ID: 251103.0, MPI für evolutionäre Anthropologie / Publications MPI for Evolutionary Anthropology
No evidence of Neandertal mtDNA contribution to early modern humans
Authors:Serre, David; Langaney, A.; Chell, M.; Teschler-Nicola, M.; Paunovic, Maja; Mennecier, P.; Hofreiter, Michael; Possnert, G.; Pääbo, Svante
Language:English
Date of Publication (YYYY-MM-DD):2004
Title of Journal:PLoS Biology
Journal Abbrev.:PLoS Biol
Volume:2
Issue / Number:3
Start Page:313
End Page:317
Sequence Number of Article:e57
Copyright:© 2004 Serre et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The retrieval of mitochondrial DNA (mtDNA) sequences from four Neandertal fossils from Germany, Russia, and Croatia has demonstrated that these individuals carried closely related mtDNAs that are not found among current humans. However, these results do not definitively resolve the question of a possible Neandertal contribution to the gene pool of modern humans since such a contribution might have been erased by genetic drift or by the continuous influx of modern human DNA into the Neandertal gene pool. A further concern is that if some Neandertals carried mtDNA sequences similar to contemporaneous humans, such sequences may be erroneously regarded as modern contaminations when retrieved from fossils. Here we address these issues by the analysis of 24 Neandertal and 40 early modern human remains. The biomolecular preservation of four Neandertals and of five early modern humans was good enough to suggest the preservation of DNA. All four Neandertals yielded mtDNA sequences similar to those previously determined from Neandertal individuals, whereas none of the five early modern humans contained such mtDNA sequences. In combination with current mtDNA data, this excludes any large genetic contribution by Neandertals to early modern humans, but does not rule out the possibility of a smaller contribution.
External Publication Status:published
Document Type:Article
Communicated by:Gisela Lausberg
Affiliations:MPI für evolutionäre Anthropologie/Department of Evolutionary Genetics
External Affiliations:Laboratoire d'Anthropologie Biologique, Musée de l'Homme, Paris, France
Laboratoire de Génétique et Biométrie, Université de Genève, Genève, Switzerland
Department of Anthropology, Natural History Museum, Vienna, Austria
Institute of Quaternary Paleontology and Geology, Croatian Academy of Sciences and Arts, Zagreb, Croatia, 6 Ångström Laboratory, Uppsala University, Uppsala, Sweden
Identifiers:DOI:10.1371/journal.pbio.0020057
URL:http://biology.plosjournals.org/perlserv/?request=...
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