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          Institute: MPI für evolutionäre Anthropologie     Collection: Publications MPI for Evolutionary Anthropology     Display Documents



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ID: 251104.0, MPI für evolutionäre Anthropologie / Publications MPI for Evolutionary Anthropology
A Neutral Model of Transcriptome Evolution
Authors:Khaitovich, Philipp; Weiss, Gunter; Lachmann, Michael; Hellmann, Ines; Enard, Wolfgang; Muetzel, Bjoern; Wirkner, Ute; Ansorge, Wilhelm; Pääbo, Svante
Language:English
Date of Publication (YYYY-MM-DD):2004-05
Title of Journal:PLoS Biology
Volume:2
Issue / Number:5
Start Page:0682
End Page:0689
Sequence Number of Article:e132
Copyright:© 2004 Khaitovich et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for changes in the expression levels of many genes, it is not known whether the majority of changes of gene expression fixed during evolution between species and between various tissues within a species are caused by Darwinian selection or by stochastic processes. We find the following: (1) expression differences between species accumulate approximately linearly with time; (2) gene expression variation among individuals within a species correlates positively with expression divergence between species; (3) rates of expression divergence between species do not differ significantly between intact genes and expressed pseudogenes; (4) expression differences between brain regions within a species have accumulated approximately linearly with time since these regions emerged during evolution. These results suggest that the majority of expression differences observed between species are selectively neutral or nearly neutral and likely to be of little or no functional significance. Therefore, the identification of gene expression differences between species fixed by selection should be based on null hypotheses assuming functional neutrality. Furthermore, it may be possible to apply a molecular clock based on expression differences to infer the evolutionary history of tissues.
External Publication Status:published
Document Type:Article
Communicated by:Gisela Lausberg
Affiliations:MPI für evolutionäre Anthropologie/Department of Evolutionary Genetics
External Affiliations:WE Informatik, Bioinformatik, University of Düsseldorf, Düsseldorf, Germany
European Molecular Biology Laboratory, Heidelberg, Germany
Identifiers:DOI:10.1371/journal.pbio.0020132
URL:http://biology.plosjournals.org/perlserv/?request=...
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