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          Institute: MPI für molekulare Pflanzenphysiologie     Collection: Publikationen Pflanzenphysiologie     Display Documents

ID: 251376.0, MPI für molekulare Pflanzenphysiologie / Publikationen Pflanzenphysiologie
GC-MS libraries for the rapid identification of metabolites in complex biological samples
Authors:Schauer, N.; Steinhauser, D.; Strelkov, S.; Schomburg, D.; Allison, G.; Moritz, T.; Lundgren, K.; Roessner-Tunali, U.; Forbes, M. G.; Willmitzer, L.; Fernie, A. R.; Kopka, J.
Date of Publication (YYYY-MM-DD):2005-02-28
Title of Journal:FEBS Letters
Journal Abbrev.:Febs Lett
Issue / Number:6
Start Page:1332
End Page:1337
Review Status:not specified
Audience:Not Specified
Abstract / Description:Gas chromatography-mass spectrometry based metabolite profiling of biological samples is rapidly becoming one of the cornerstones of functional genomics and systems biology. Thus, the technology needs to be available to many laboratories and open exchange of information is required such as those achieved for transcript and protein data. The key-step in metabolite profiling is the unambiguous identification of metabolites in highly complex metabolite preparations with composite structure. Collections of mass spectra, which comprise frequently observed identified and non-identified metabolites, represent the most effective means to pool the identification efforts currently performed in many laboratories around the world. Here, we describe a platform for mass spectral and retention time index libraries that will enable this process (MSRI; www.csbdb.mpimpgolm.mpg.delgmd.html). This resource should ameliorate many of the problems that each laboratory will face both for the initial establishment of metabolome analysis and for its maintenance at a constant sample throughput. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Free Keywords:gc-ms
; gas chromatography-mass spectrometry
; mass spectral library
; metabolite profiling
; metabolomics
; retention time index
; gas chromatography/mass spectrometry
; mass-spectrometry
; corynebacterium-glutamicum
; functional genomics
; metabolomics
; database
; nutrigenomics
; extraction
; systems
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:N. N.
Affiliations:MPI für molekulare Pflanzenphysiologie/Molekulare Physiologie/AG Willmitzer/Fernie
MPI für molekulare Pflanzenphysiologie/Molekulare Physiologie/AG Kopka
External Affiliations:Max Planck Inst Plant Mol Physiol, Muehlenberg 1, D-14476 Golm, Germany
Max Planck Inst Plant Mol Physiol, D-14476 Golm, Germany
Univ Cologne, CUBIC, Inst Biochem, D-50674 Cologne, Germany
Inst Food Res, Inst Grassland & Environm Res, Aberystwyth SY23 3EB, Dyfed, Wales
Swedish Univ Agr Sci, Dept Forest Genet & Plant Physiol, Umea Plant Sci Ctr, SE-90183 Umea, Sweden
Univ Melbourne, Sch Bot, Australian Ctr Plant Funct Genom, Melbourne, Vic 3010, Australia
Identifiers:ISI:000227393700003 [ID No:1]
ISI:000227393700003 [ID No:2]
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