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          Institute: MPI für evolutionäre Anthropologie     Collection: Publications MPI for Evolutionary Anthropology     Display Documents

ID: 251498.0, MPI für evolutionäre Anthropologie / Publications MPI for Evolutionary Anthropology
Systematic analysis of gene expression in human brains before and after death
Authors:Franz, Henriette; Ullmann, C.; Becker, A.; Ryan, Michael; Bahn, Sabine; Arendt, Thomas; Simon, M.; Pääbo, Svante; Khaitovich, Philipp
Date of Publication (YYYY-MM-DD):2005
Title of Journal:Genome Biology
Journal Abbrev.:Genome Biol
Issue / Number:13
Start Page:R112.1
End Page:R112.9
Sequence Number of Article:R112
Review Status:not specified
Audience:Not Specified
Abstract / Description:BACKGROUND: Numerous studies have employed microarray techniques to study changes in gene expression in connection with human disease, aging and evolution. The vast majority of human samples available for research are obtained from deceased individuals. This raises questions about how well gene expression patterns in such samples reflect those of living individuals. RESULTS: Here, we compare gene expression patterns in two human brain regions in postmortem samples and in material collected during surgical intervention. We find that death induces significant expression changes in more than 10% of all expressed genes. These changes are non-randomly distributed with respect to their function. Moreover, we observe similar expression changes due to death in two distinct brain regions. Consequently, the pattern of gene expression differences between the two brain regions is largely unaffected by death, although the magnitude of differences is reduced by 50% in postmortem samples. Furthermore, death-induced changes do not contribute significantly to gene expression variation among postmortem human brain samples. CONCLUSION: We conclude that postmortem human brain samples are suitable for investigating gene expression patterns in humans, but that caution is warranted in interpreting results for individual genes.
External Publication Status:published
Document Type:Article
Communicated by:Gisela Lausberg
Affiliations:MPI für evolutionäre Anthropologie/Department of Evolutionary Genetics
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