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          Institute: MPI für evolutionäre Anthropologie     Collection: Publications MPI for Evolutionary Anthropology     Display Documents



  history
ID: 251554.0, MPI für evolutionäre Anthropologie / Publications MPI for Evolutionary Anthropology
Initial sequence of the chimpanzee genome and comparison with the human genome
Authors:Mikkelsen, Tarjei S.; Hillier, LaDeana W.; Eichler, Evan E.; Zody, Michael C.; Jaffe, David B.; Yang, Shiaw-Pyng; Enard, Wolfgang; Hellmann, Ines; Lindblad-Toh, Kerstin; Altheide, Tasha K.; Archidiacono, Nicoletta; Bork, Peer; Butler, Jonathan; Chang, Jean L.; Cheng, Ze; Chinwalla, Asif T.; de Jong, Pieter; Delehaunty, Kimberley D.; Fronick, Catrina C.; Fulton, Lucinda L.; Gilad, Yoav; Glusman, Gustavo; Gnerre, Sante; Graves, Tina A.; Hayakawa, Toshiyuki; Hayden, Karen E.; Huang, Xiaoqiu; Ji, Hongkai; Kent, W. James; King, Mary-Claire; Kulbokasl, Edward J.; Lee, Ming K.; Liu, Ge; Lopez-Otin, Carlos; Makova, Kateryna D.; Man, Orna; Mardis, Elaine R.; Mauceli, Evan; Miner, Tracie L.; Nash, William E.; Nelson, Joanne O.; Pääbo, Svante; Patterson, Nick J.; Pohl, Craig S.; Pollard, Katherine S.; Prüfer, Kay; Puente, Xose S.; Reich, David; Rocchi, Mariano; Rosenbloom, Kate; Ruvolo, Maryellen; Richter, Daniel J.; Schaffner, Stephen F.; Smit, Arian F. A.; Smith, Scott M.; Suyama, Mikita; Taylor, James; Torrents, David; Tuzun, Eray; Varki, Ajit; Velasco, Gloria; Ventura, Mario; Wallis, John W.; Wendl, Michael C.; Wilson, Richard K.; Lander, Eric S.; Waterston, Robert H.
Language:English
Date of Publication (YYYY-MM-DD):2005-09-01
Title of Journal:Nature
Volume:437
Issue / Number:7055
Start Page:69
End Page:87
Review Status:not specified
Audience:Not Specified
Abstract / Description:Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements. We use this catalogue to explore the magnitude and regional variation of mutational forces shaping these two genomes, and the strength of positive and negative selection acting on their genes. In particular, we find that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles. We also use the chimpanzee genome as an outgroup to investigate human population genetics and identify signatures of selective sweeps in recent human evolution. (PsycINFO Database Record (c) 2006 APA, all rights reserved) (journal abstract).
Free Keywords:*Chimpanzees
; *Genome
; *Mutations
; Genes
; Genetics
; Genetics [2510]; Animal Experimental & Comparative Psychology
; [2400].
External Publication Status:published
Document Type:Article
Communicated by:Gisela Lausberg
Affiliations:MPI für evolutionäre Anthropologie/Department of Evolutionary Genetics
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