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          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents

ID: 267502.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
The SYSTERS Protein Family Database in 2005
Authors:Meinel, Thomas; Krause, Antje; Luz, Hannes; Vingron, Martin; Staub, Eike
Title of Journal:Nucleic Acids Research (London)
Journal Abbrev.:Nucleic Acids Res
Start Page:D226
End Page:D229
Title of Issue:Database issue
Copyright:© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved
Review Status:not specified
Audience:Experts Only
Abstract / Description:The SYSTERS project aims to provide a meaningful partitioning of the whole protein sequence space by a fully automatic procedure. A refined two-step algorithm assigns each protein to a family and a superfamily. The sequence data underlying SYSTERS release 4 now comprise several protein sequence databases derived from completely sequenced genomes (ENSEMBL, TAIR, SGD and GeneDB), in addition to the comprehensive Swiss-Prot/TrEMBL databases. The SYSTERS web server ( provides access to 158 153 SYSTERS protein families. To augment the automatically derived results, information from external databases like Pfam and Gene Ontology are added to the web server. Furthermore, users can retrieve pre-processed analyses of families like multiple alignments and phylogenetic trees. New query options comprise a batch retrieval tool for functional inference about families based on automatic keyword extraction from sequence annotations. A new access point, PhyloMatrix, allows the retrieval of phylogenetic profiles of SYSTERS families across organisms with completely sequenced genomes.
External Publication Status:published
Document Type:Article
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:TFH Wildau, Biosystemtechnik/Bioinformatik, Bahnhofstrasse, 15745 Wildau, Germany
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