Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents



  history
ID: 268537.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
Detecting common gene expression patterns in multiple cancer outcome entities
Authors:Yang, Xinan; Bentink, Stefan; Spang, Rainer
Language:English
Date of Publication (YYYY-MM-DD):2005-09-01
Title of Journal:Biomedical Microdevices
Journal Abbrev.:Biomed Microdevices
Volume:7
Issue / Number:3
Start Page:247
End Page:251
Copyright:© Springer
Review Status:not specified
Audience:Experts Only
Abstract / Description:Most oncological microarray studies focus on molecular distinctions in different cancer entities. Recently, researchers started using microarrays for investigating molecular commonalities of multiple cancer types. This poses novel bioinformatics challenges.
In this paper we describe a method that detects common molecular mechanisms in different cancer entities. The method extends previously described concepts by introducing Meta-Analysis Pattern Matches. In an analysis of four prognostic cancer studies, involving breast cancer, leukemia, and mesothelioma, we are able to identify 42 genes that show consistent up- or down-regulation in patients with a poor disease outcome. These genes complement the set of previously published candidates for universal prognostic markers in cancer.
Free Keywords:molecular cancer mechanisms
meta-analysis
computational diagnostics
microarrays
bioinformatics
External Publication Status:published
Document Type:Article
Version Comment:Automatic journal name synchronization
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:State Key Laboratory of Bioelectronics, Southeast University, 210096 Nanjing, P. R. China.
Identifiers:DOI:10.1007/s10544-005-3032-7
ISSN:1387-2176
Full Text:
Sorry, no privileges
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.