Please note that eDoc will be permanently shut down in the first quarter of 2021!      Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen mpi-cbg 2003     Display Documents



ID: 27023.0, MPI für molekulare Zellbiologie und Genetik / Publikationen mpi-cbg 2003
XMAP215: a key component of the dynamic microtubule cytoskeleton
Authors:Kinoshita, Kazuhisa; Habermann, Bianca; Hyman, Anthony A.
Date of Publication (YYYY-MM-DD):2002
Title of Journal:Trends in Cell Biology
Volume:12
Issue / Number:6
Start Page:267
End Page:273
Review Status:not specified
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Microtubules are essential for various cellular processes including cell division and intracellular organization. Their function depends on their ability to rearrange their distribution at different times and places. Microtubules are dynamic polymers and their behaviour is described as dynamic instability. Rearrangement of the microtubule cytoskeleton is made possible by proteins that modulate the parameters of dynamic instability. Studies using Xenopus egg extracts led to identification of a microtubule-associated protein called XMAP215 as a major regulator of physiological microtubule dynamics. XMAP215 belongs to an evolutionarily conserved protein family present in organisms ranging from yeast to mammals. Together with members of the Kin I family of kinesins, XMAP215 and its orthologues form an essential circuit for generating dynamic microtubules in vivo.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:87
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.