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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



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ID: 271577.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality
Authors:Hitz, Christiane; Vogt-Weisenhorn, Daniela; Ruiz, Patricia; Wurst, Wolfgang; Floss, Thomas
Language:English
Date of Publication (YYYY-MM-DD):2005-05-10
Title of Journal:Genesis
Volume:42
Issue / Number:2
Start Page:91
End Page:103
Copyright:© 2005 Wiley-Liss, Inc.
Review Status:not specified
Audience:Experts Only
Abstract / Description:We have generated a mouse line with a mutant allele of the mouse Bruce/Birc6 gene induced by gene trap mutagenesis. Based on its structural features, Bruce is a member of the family of apoptosis inhibitor proteins (IAPs). This mutation leads to a truncated transcript and protein and results in a complete loss of the wildtype Bruce protein. Bruce mutant mice die from a progressive loss of their placental spongiotrophoblast layer between day 11.5 and 14.5 of embryonic development. The cause of the Bruce homozygous mutant phenotype is a lack of proliferation of spongiotrophoblast cells in the developing placenta. In contrast to in vitro data, which indicate a function for Bruce in apoptosis inhibition, the in vivo results presented here suggest instead a role for Bruce in cell division.
Free Keywords:IAP; apoptosis; spongiotrophoblast; gene trap
Comment of the Author/Creator:Email: Wolfgang Wurst (wurst@gsf.de) Thomas Floss (tfloss@gsf.de)
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany;
Max-Planck-Institute of Psychiatry, Molecular Neurogenetics, Munich, Germany
Identifiers:ISSN:1526-954X
DOI:10.1002/gene.20128
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