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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents

ID: 273144.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Genome projects and the functional-genomic era
Authors:Sauer, Sascha; Konthur, Zoltan; Lehrach, Hans
Date of Publication (YYYY-MM-DD):2005-12
Title of Journal:Combinatorial Chemistry & High Throughput Screening
Issue / Number:8
Start Page:659
End Page:667
Copyright:© 2006 Ingenta
Review Status:not specified
Audience:Experts Only
Abstract / Description:The problems we face today in public health as a result of the - fortunately - increasing age of people and the requirements of developing countries create an urgent need for new and innovative approaches in medicine and in agronomics. Genomic and functional genomic approaches have a great potential to at least partially solve these problems in the future. Important progress has been made by procedures to decode genomic information of humans, but also of other key organisms. The basic comprehension of genomic information (and its transfer) should now give us the possibility to pursue the next important step in life science eventually leading to a basic understanding of biological information flow; the elucidation of the function of all genes and correlative products encoded in the genome, as well as the discovery of their interactions in a molecular context and the response to environmental factors. As a result of the sequencing projects, we are now able to ask important questions about sequence variation and can start to comprehensively study the function of expressed genes on different levels such as RNA, protein or the cell in a systematic context including underlying networks. In this article we review and comment on current trends in large-scale systematic biological research. A particular emphasis is put on technology developments that can provide means to accomplish the tasks of future lines of functional genomics.
Free Keywords:Functional genomics; genotyping; expression analysis; proteomics; RNAi; cell; microarray
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
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