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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 273215.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
SVC: Structured visualization of evolutionary sequence conservation
Translation of Title:SVC: Structured visualization of evolutionary sequence conservation
Authors:Roepcke, S.; Fiziev, P.; Seeburg, Peter H.; Vingron, M.
Language:English
Date of Publication (YYYY-MM-DD):2005-07-01
Title of Journal:Nucleic Acids Research
Journal Abbrev.:Nucleic Acids Res.
Volume:33
Issue / Number:12
Start Page:271
End Page:273
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:We have developed a web application for the detailed analysis and visualization of evolutionary sequence conservation in complex vertebrate genes. Given a pair of orthologous genes, the protein−coding sequences are aligned. When these sequences are mapped back onto their encoding exons in the genomes, a scaffold of the conserved gene structure naturally emerges. Sequence similarity between exons and introns is analysed and embedded into the gene structure scaffold. The visualization on the SVC server provides detailed information about evolutionarily conserved features of these genes. It further allows concise representation of complex splice patterns in the context of evolutionary conservation. A particular application of our tool arises from the fact that around mRNA editing sites both exonic and intronic sequences are highly conserved. This aids in delineation of these sites. SVC is available at http://svc.molgen.mpg.de.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Relations:Has References-URI:http://nar.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=pnas&resid=93/5/1875
Has References-URI:http://nar.oxfordjournals.org/cgi/external_ref?access_num=7536132&link_type=MED
Has References-URI:http://nar.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=genome&resid=13/7/1631
Has References-URI:http://nar.oxfordjournals.org/cgi/external_ref?access_num=12730695&link_type=MED
Has References-URI:http://nar.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=nar&resid=32/suppl_1/D64
Identifiers:LOCALID:6520
URI:http://nar.oxfordjournals.org/cgi/search?sendit=Se...
URI:http://nar.oxfordjournals.org/cgi/content/full/33/...
URI:http://nar.oxfordjournals.org/cgi/content/abstract...
DOI:10.1093/nar/gki589
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