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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 273220.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA Receptors
Translation of Title:Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA Receptors
Authors:Shimshek, Derya R.; Bus, Thorsten; Kim, Jinhyun; Mihaljevic, André; Mack, Volker; Seeburg, Peter H.; Sprengel, Rolf; Schaefer, Andreas T.
Language:English
Date of Publication (YYYY-MM-DD):2005-10-18
Title of Journal:PLoS Biology
Journal Abbrev.:PLoS Biol.
Volume:3
Issue / Number:11
Start Page:2017
End Page:2030
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Genetic perturbations of á−amino−3−hydroxy−5−methyl−4−isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study, we investigated the role of Ca2+−permeable AMPARs in olfactory behavior. AMPAR modification was obtained by depletion of the GluR−B subunit or expression of unedited GluR−B(Q), both leading to increased Ca2+ permeability of AMPARs. Mice with this functional AMPAR switch, specifically in forebrain, showed enhanced olfactory discrimination and more rapid learning in a go/no−go operant conditioning task. Olfactory memory, however, was dramatically impaired. GluR−B depletion in forebrain was ectopically variable (
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie
Identifiers:LOCALID:6479
URI:http://biology.plosjournals.org/perlserv/?request=...
URI:http://biology.plosjournals.org/perlserv/?request=...
URI:http://biology.plosjournals.org/perlserv/?request=...
DOI:10.1371/journal.pbio.0030354
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