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          Institute: MPI für medizinische Forschung     Collection: Abteilung Zellphysiologie     Display Documents



ID: 273246.0, MPI für medizinische Forschung / Abteilung Zellphysiologie
Lack of NMDAR subtype selectivity for hippocampal LTP
Translation of Title:Lack of NMDAR subtype selectivity for hippocampal LTP
Authors:Berberich, Sven; Punnakkal, Pradeep; Jensen, Vidar; Pawlak, Verena; Seeburg, Peter H.; Hvalby, Øivind; Köhr, Georg
Language:English
Date of Publication (YYYY-MM-DD):2005-07-20
Title of Journal:Journal of Neuroscience
Journal Abbrev.:J. Neurosci.
Volume:25
Issue / Number:29
Start Page:6907
End Page:6910
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:NMDA receptor (NMDAR) 2A (NR2A)− and NR2B−type NMDARs coexist in synapses of CA1 pyramidal cells. Recent studies using pharmacological blockade of NMDAR subtypes proposed that the NR2A type is responsible for inducing long−term potentiation (LTP), whereas the NR2B type induces long−term depression (LTD). This contrasts with the finding in genetically modified mice that NR2B−type NMDARs induce LTP when NR2A signaling is absent or impaired, although compensatory mechanisms might have contributed to this result. We therefore assessed the contribution of the two NMDAR subtypes to LTP in mouse hippocampal slices by different induction protocols and in the presence of NMDAR antagonists, including the NR2A−type blocker NVP−AAM077, for which an optimal concentration for subtype selectivity was determined on recombinant and native NMDARs. Partial blockade of NMDA EPSCs by 40%, either by preferentially antagonizing NR2A− or NR2B−type NMDARs or by the nonselective antagonist D−AP−5, did not impair LTP, demonstrating that hippocampal LTP induction can be generated by either NMDAR subtype.
Free Keywords:NVP−AAM077; PEAQX; CP−101,606; recombinant; gene−targeted mouse; partial blockade; pairing
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
MPI für medizinische Forschung/Abteilung Zellphysiologie
Relations:Has References-URI:http://www.jneurosci.org/cgi/ijlink?linkType=ABST&journalCode=pnas&resid=99/22/14500
Has References-URI:http://www.jneurosci.org/cgi/ijlink?linkType=ABST&journalCode=jphysiol&resid=507/1/13
Has References-URI:http://www.jneurosci.org/cgi/ijlink?linkType=ABST&journalCode=jneuro&resid=20/3/1260
Has References-URI:http://www.jneurosci.org/cgi/ijlink?linkType=ABST&journalCode=jneuro&resid=22/22/9687
Has References-URI:http://www.jneurosci.org/cgi/ijlink?linkType=ABST&journalCode=jneuro&resid=24/36/7821
Identifiers:LOCALID:6439
URI:http://www.jneurosci.org/cgi/reprint/25/29/6907?ma...
URI:http://www.jneurosci.org/cgi/content/full/25/29/69...
URI:http://www.jneurosci.org/cgi/content/abstract/25/2...
DOI:10.1523/JNEUROSCI.1905-05.2005
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