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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents

ID: 27859.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
Expression of the helix-loop-helix gene id3 in the zebrafish embryo
Authors:Dickmeis, Thomas; Rastegar, Sepand; Lam, Chen Sok; Aanstad, Pia; Clark, Matthew; Fischer, Nadine; Rosa, Frédéric; Korzh, Vladimir; Strähle, Uwe
Date of Publication (YYYY-MM-DD):2002-01-30
Title of Journal:Mechanisms of Development
Journal Abbrev.:Mech Dev
Issue / Number:1
Start Page:99
End Page:102
Review Status:not specified
Audience:Experts Only
Abstract / Description:Proteins of the Extramacrochaetae and Id subfamily of Helix-Loop-Helix (HLH) proteins are negative regulators of bHLH transcription factors. We cloned a cDNA from zebrafish which encodes a member of the id3 subfamily. High levels of transcripts accumulated in the germ ring and in the embryonic shield. Towards the end of gastrulation, Id3 was highly expressed in the anterior prechordal plate and hypoblast. At later stages, id3 expression was turned on and off in a large variety of tissues within short periods of time. These include the lateral mesoderm, the cornea, the lens, the brain, the neural crest, the retina and the fins.
Free Keywords:Helix–loop–helix; Extramacrochaetae; id3; Germ ring; Embryonic shield; Retina
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, F-67404 Illkirch Cedex, C.U. de Strasbourg, Strasbourg, France.
U 368 INSERM, Ecole Normale Supérieure, 46, rue d' Ulm. F-75230 Paris Cedex 05, France.
Institute of Molecular Agrobiology, National University of Singapore, 1 Research Link, Singapore.
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