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Home Search Quick Search Advanced Fulltext Browse Collections Persons My eDoc Session History Login Name: Password: Documentation Help Support Wiki Direct access to document ID:	Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents ID: 27859.0, MPI für molekulare Genetik / Department of Vertebrate Genomics Expression of the helix-loop-helix gene id3 in the zebrafish embryo Authors: Dickmeis, Thomas; Rastegar, Sepand; Lam, Chen Sok; Aanstad, Pia; Clark, Matthew; Fischer, Nadine; Rosa, Frédéric; Korzh, Vladimir; Strähle, Uwe Language: English Date of Publication (YYYY-MM-DD): 2002-01-30 Title of Journal: Mechanisms of Development Journal Abbrev.: Mech Dev Volume: 113 Issue / Number: 1 Start Page: 99 End Page: 102 Review Status: not specified Audience: Experts Only Abstract / Description: Proteins of the Extramacrochaetae and Id subfamily of Helix-Loop-Helix (HLH) proteins are negative regulators of bHLH transcription factors. We cloned a cDNA from zebrafish which encodes a member of the id3 subfamily. High levels of transcripts accumulated in the germ ring and in the embryonic shield. Towards the end of gastrulation, Id3 was highly expressed in the anterior prechordal plate and hypoblast. At later stages, id3 expression was turned on and off in a large variety of tissues within short periods of time. These include the lateral mesoderm, the cornea, the lens, the brain, the neural crest, the retina and the fins. Free Keywords: Helix–loop–helix; Extramacrochaetae; id3; Germ ring; Embryonic shield; Retina External Publication Status: published Document Type: Article Communicated by: Hans Lehrach Affiliations: MPI für molekulare Genetik External Affiliations: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, F-67404 Illkirch Cedex, C.U. de Strasbourg, Strasbourg, France. U 368 INSERM, Ecole Normale Supérieure, 46, rue d' Ulm. F-75230 Paris Cedex 05, France. Institute of Molecular Agrobiology, National University of Singapore, 1 Research Link, Singapore. The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.