Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Infektionsbiologie     Collection: Department of Molecular Biology     Display Documents



  history
ID: 286084.0, MPI für Infektionsbiologie / Department of Molecular Biology
Who Ate Whom? Adaptive Helicobacter Genomic Changes That Accompanied a Host Jump from Early Humans to Large Felines
Authors:Eppinger, Mark; Baar, Claudia; Linz, Bodo; Raddatz, Günter; Lanz, Christa; Keller, Heike; Morelli, Giovanna; Gressmann, Helga; Achtman, Mark; Schuster, Stephan C.
Language:English
Date of Publication (YYYY-MM-DD):2006-07-28
Title of Journal:PLoS Genetics
Journal Abbrev.:PLoS Genet
Volume:2
Issue / Number:7
Start Page:1097
End Page:1110
Sequence Number of Article:e120
Copyright:© 2006 Eppinger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Helicobacter pylori infection of humans is so old that its population genetic structure reflects that of ancient human migrations. A closely related species, Helicobacter acinonychis, is specific for large felines, including cheetahs, lions, and tigers, whereas hosts more closely related to humans harbor more distantly related Helicobacter species. This observation suggests a jump between host species. But who ate whom and when did it happen? In order to resolve this question, we determined the genomic sequence of H. acinonychis strain Sheeba and compared it to genomes from H. pylori. The conserved core genes between the genomes are so similar that the host jump probably occurred within the last 200,000 (range 50,000–400,000) years. However, the Sheeba genome also possesses unique features that indicate the direction of the host jump, namely from early humans to cats. Sheeba possesses an unusually large number of highly fragmented genes, many encoding outer membrane proteins, which may have been destroyed in order to bypass deleterious responses from the feline host immune system. In addition, the few Sheeba-specific genes that were found include a cluster of genes encoding sialylation of the bacterial cell surface carbohydrates, which were imported by horizontal genetic exchange and might also help to evade host immune defenses. These results provide a genomic basis for elucidating molecular events that allow bacteria to adapt to novel animal hosts.
External Publication Status:published
Document Type:Article
Communicated by:Hilmar Fünning
Affiliations:MPI für Infektionsbiologie/Department of Molecular Biology
MPI für Entwicklungsbiologie
External Affiliations:Department of Biochemistry and Molecular Biology, Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, Pennsylvania, United States of America,
Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, Pennsylvania, United States of America
Identifiers:URL:http://genetics.plosjournals.org/perlserv/?request...
DOI:10.1371/journal.pgen.0020120
Full Text:
You have privileges to view the following file(s):
PLoS_Genet_2(7)_e120.pdf  [3,00 Mb]   
 
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.