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          Institute: MPI für Pflanzenzüchtungsforschung     Collection: Dept. Plant Microbe Interactions (Paul Schulze-Lefert)     Display Documents



ID: 28802.0, MPI für Pflanzenzüchtungsforschung / Dept. Plant Microbe Interactions (Paul Schulze-Lefert)
Arabidopsis RAR1 exerts rate-limiting control of R gene- mediated defenses against multiple pathogens
Authors:Muskett, P. R.; Kahn, K.; Austin, M. J.; Moisan, L. J.; Sadanandom, A.; Shirasu, K.; Jones, J. D. G.; Parker, J. E.
Language:English
Date of Publication (YYYY-MM-DD):2002-05
Title of Journal:Plant Cell
Journal Abbrev.:Plant Cell
Volume:14
Issue / Number:5
Start Page:979
End Page:992
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:We have identified the Arabidopsis ortholog of barley RAR1 as a component of resistance specified by multiple nucleotide binding/Leu-rich repeat resistance (R) genes recognizing different bacterial and oomycete pathogen isolates. Characterization of partially and fully defective rar1 mutations revealed that wild-type RAR1 acts as a rate-limiting regulator of early R gene-triggered defenses, determining the extent of pathogen containment, hypersensitive plant cell death, and an oxidative burst at primary infection sites. We conclude that RAR1 defense signaling function is conserved between plant species that are separated evolutionarily by 150 million years. RAR1 encodes a protein with two zinc binding (CHORD) domains that are highly conserved across eukaryotic phyla, and the single nematode CHORD-containing homolog, Chp, was found previously to be essential for embryo viability. An absence of obvious developmental defects in null Arabidopsis rar1 mutants favors the notion that, in contrast, RAR1 does not play a fundamental role in plant development.
Comment of the Author/Creator:Date: 2002, MAY
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Pflanzenzüchtungsforschung
External Affiliations:John Innes Ctr Plant Sci Res, Sainsbury Lab, Norwich NR4 7UH,; Norfolk, England; Max Plant Inst Plant Breeding Res, Dept Mol Plant Pathol, D-50829 Cologne, Germany
Identifiers:ISI:000176070200003 [ID No:1]
ISSN:1040-4651 [ID No:2]
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