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          Institute: MPI für Pflanzenzüchtungsforschung     Collection: Dept. Plant Microbe Interactions (Paul Schulze-Lefert)     Display Documents



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ID: 28821.0, MPI für Pflanzenzüchtungsforschung / Dept. Plant Microbe Interactions (Paul Schulze-Lefert)
The RAR1 interactor SGT1, an essential component of R gene- triggered disease resistance
Authors:Azevedo, C.; Sadanandom, A.; Kitagawa, K.; Freialdenhoven, A.; Shirasu, K.; Schulze-Lefert, P.
Language:English
Date of Publication (YYYY-MM-DD):2002-03-15
Title of Journal:Science
Journal Abbrev.:Science
Volume:295
Issue / Number:5562
Start Page:2073
End Page:2076
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence: point in a signaling pathway engaged by multiple R genes. Here, vie show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene- triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.
Comment of the Author/Creator:Date: 2002, MAR 15
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Pflanzenzüchtungsforschung
External Affiliations:John Innes Ctr Plant Sci Res, Sainsbury Lab, Colney Lane,; Norwich NR4 7UH, Norfolk, England; John Innes Ctr Plant Sci Res, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England; St Jude Childrens Hosp, Dept Mol Pharmacol, Memphis, TN 38105 USA; Max Planck Inst Zuchtungsforsch, Biochem Abt, D-50829 Cologne, Germany
Identifiers:ISI:000174450500049 [ID No:1]
ISSN:0036-8075 [ID No:2]
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