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          Institute: MPI für Biochemie     Collection: Molecular Medicine (R. Fässler)     Display Documents



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ID: 28933.0, MPI für Biochemie / Molecular Medicine (R. Fässler)
The murine latent transforming growth factor-β binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22
Authors:Weiskirchen, R.; Moser, M.; Günther, K.; Weiskirchen, S.; Gressner, A. M.
Language:English
Date of Publication (YYYY-MM-DD):2003-04-10
Title of Journal:Gene
Journal Abbrev.:Gene
Volume:308
Start Page:43
End Page:52
Review Status:Peer-review
Audience:Not Specified
Abstract / Description:The latent transforming growth factor-beta (TGF-beta) binding protein-1 belongs to a family of matrix glycoproteins that is functionally associated with the assembly and secretion of TGF- beta. We have isolated and sequenced a murine similar to 15-kbp contig containing part of Ltbp-1 and used a mouse-hamster radiation hybrid panel to determine its chromosomal localization on distal mouse chromosome 17. This map location is syntenic to human chromosomal subband 2p21-22. Similarly, human LTBP-1 was mapped to 2p21-22 by fluorescence in situ hybridization. Like in humans, the murine Ltbp-1 gene directs the synthesis of two different transcript sizes encoding two alternatively spliced isoforms (Ltbp-1S and Ltbp-1L), which are regulated in a tissue-and stage-dependent manner. Sequence analysis and database searches further reveal that the upstream regions of both isoforms are devoid of TATA and CAAT boxes but contain other putative binding sites for several transcription factors conserved in mouse and human. The utilization of different promoters and their evolutionarily conservation further emphasize the complex regulation of Ltbp-1. (C) 2003 Elsevier Science B.V. All rights reserved.
Free Keywords:latent transforming growth factor binding protein-1; transforming growth factor-beta 1; whole-genome-radiation panel; T31
Comment of the Author/Creator:Date: 2003, APR 10
External Publication Status:published
Document Type:Article
Communicated by:N.N.
Affiliations:MPI für Biochemie/Molecular Medicine (R. Fässler)
MPI für Biochemie/Molecular Medicine (R. Fässler)/Research Group Moser
External Affiliations:RWTH Univ Hosp Aachen, Inst Clin Chem & Pathobiochem,; Pauwelsstr 30, D-52074 Aachen, Germany; RWTH Univ Hosp Aachen, Inst Clin Chem & Pathobiochem, D-52074 Aachen, Germany; RWTH Univ Hosp Aachen, Clin Urol, D-52074 Aachen, Germany
Identifiers:ISI:000182939500005 [ID No:1]
ISSN:0378-1119 [ID No:2]
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