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          Institute: MPI für molekulare Genetik     Collection: Department of Vertebrate Genomics     Display Documents



ID: 29198.0, MPI für molekulare Genetik / Department of Vertebrate Genomics
The genome sequence of Schizosaccharomyces pombe
Authors:Wood, V.; Gwilliam, R.; Rajandream, M. A.; Lyne, M.; Lyne, R.; Stewart, A.; Sgouros, J.; Peat, N.; Hayles, J.; Baker, S.; Basham, D.; Bowman, S.; Brooks, K.; Brown, D.; Brown, S.; Chillingworth, T.; Churcher, C.; Collins, M.; Connor, R.; Cronin, A.; Davis, P.; Feltwell, T.; Fraser, A.; Gentles, S.; Goble, A.; Hamlin, N.; Harris, D.; Hidalgo, J.; Hodgson, G.; Holroyd, S.; Hornsby, T.; Howarth, S.; Huckle, E. J.; Hunt, S.; Jagels, K.; James, K.; Jones, L.; Jones, M.; Odell, C.; Oliver, K.; O'Neil, S.; Pearson, D.; Quail, M. A.; Rabbinowitsch, E.; Rutherford, K.; Rutter, S.; Saunders, D.; Seeger, K.; Sharp, S.; Skelton, J.; Simmonds, M.; Squares, R.; Stevens, K.; Taylor, K.; Taylor, R. G.; Tivey, A.; Walsh, S.; Warren, T.; Whitehead, S.; Woodward, J.; Volckaert, G.; Aert, R.; Robben, J.; Grymonprez, B.; Weltjens, I.; Vanstreels, E.; Rieger, M.; Schäfer, M.; Müller-Auer, S.; Gabel, C.; Fuchs, M.; Fritzc, C.; Holzer, E.; Moestl, D.; Hilbert, H.; Borzym, K.; Langer, I.; Beck, A.; Lehrach, H.; Reinhardt, R.; Pohl, T. M.; Eger, P.; Zimmermann, W.; Wedler, H.; Wambutt, R.; Purnelle, B.; Goffeau, A.; Cadieu, E.; Dréano, S.; Gloux, S.; Lelaure, V.; Mottier, S.; Galibert, F.; Aves, S. J.; Xiang, Z.; Hunt, C.; Moore, K.; Hurst, S. M.; Lucas, M.; Rochet, M.; Gaillardin, C.; Tallada, V. A.; Garzon, A.; Thode, G.; Daga, R. R.; Cruzado, L.; Jimenez, J.; Sánchez, M.; Del Rey, F.; Benito, J.; Domínguez, A.; Revuelta, J. L.; Moreno, S.; Armstrong, J.; Forsburg, S. L.; Cerrutti, L.; Lowe, T.; McCombie, W. R.; Paulsen, I.; Potashkin, J.; Shpakovski, G. V.; Ussery, D.; Barrell, B. G.; Nurse, P.
Language:English
Date of Publication (YYYY-MM-DD):2002-02-21
Title of Journal:Nature
Volume:415
Issue / Number:6874
Start Page:871
End Page:880
Review Status:not specified
Audience:Experts Only
Abstract / Description:We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.
External Publication Status:published
Document Type:Article
Communicated by:Hans Lehrach
Affiliations:MPI für molekulare Genetik
External Affiliations:The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Cancer Research UK London Research Institute, Computational Genome Analysis Laboratory, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Cancer Research UK London Research Institute, Cell Cycle Laboratory, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK.
Katholieke Universiteit Leuven, Faculty of Agricultural and Applied Biological Sciences, Laboratory of Gene Technology, Kardinaal Mercierlaan 92 Blok F, B-3001 Leuven, Belgium.
Genotype GmbH, Molecular Biology and Biotech Research, Angelhofweg 39, D-69259 Wilhelmsfeld, Germany.
QIAGEN GmbH, Max Volmer Str. 4, D-40724 Hilden, Germany.
GATC Biotech AG, Jakob-Stadler-Platz 7, D-78467 Konstanz, Germany.
AGOWA GmbH, Glienicker Weg 185, D-12489 Berlin, Germany.
Université de Louvain, Unite de Biochimie Physiologique, Place Croix du Sud 2-20, B1348 Louvain-la-Neuve, Belgium.
UMR 6061 CNRS Genetique et developpement, Faculté de Médecine, 2 avenue du Professeur Léon Bernard, F-35043 Rennes Cedex, France.
University of Exeter, School of Biological Sciences, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, UK.
Génétique Moléculaire et Cellulaire, CNRS URA1925 INRA UMR216, Institut National Agronomique Paris-Grignon, 78850 Thiverval Grignon, France.
Departamento de Genetica, Facultad de Ciencias, Universidad de Malaga, Spain.
Laboratorio Andaluz de Biologia, Universidad Pablo de Olavide, Sevilla, Spain.
Instituto de Microbiología y Bioquímica, Departamento de Microbiología y Genética, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
University of Sussex, Falmer, Brighton BN1 9QG, UK.
Molecular & Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037-1099, USA.
Stanford University, Stanford University School of Medicine, Department of Genetics, CCSR Room 2255b, 269 Campus Drive, Stanford, California 94305, USA.
Cold Spring Harbor Laboratory, PO Box 100, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
TIGR, 9712 Medical Center Drive, Rockville, Maryland 20850, USA.
The Chicago Medical School, 3333 Green Bay Road, North Chicago, Illinois 60064, USA.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Center for Biological Sequence Analysis, BioCentrum-DTU, The Technical University of Denmark, Building 208, DK-2800 Kgs. Lyngby, Denmark.
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