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          Institute: MPI für experimentelle Medizin     Collection: Molecular Neurobiology     Display Documents



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ID: 292156.0, MPI für experimentelle Medizin / Molecular Neurobiology
Neuroligins determine synapse maturation and function
Authors:Varoqueaux, Frédérique; Aramuni, Gayane; Rawson, Randi L.; Mohrmann, Ralf; Missler, Markus; Gottmann, Kurt; Zhang, Weiqi; Südhof, Thomas C.; Brose, Nils
Language:English
Date of Publication (YYYY-MM-DD):2006-09
Title of Journal:Neuron
Journal Abbrev.:Neuron
Volume:51
Issue / Number:6
Start Page:741
End Page:754
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to respiratory failure. This respiratory failure is a consequence of reduced GABAergic/glycinergic and glutamatergic synaptic transmission and network activity in brainstem centers that control respiration. However, the density of synaptic contacts is not altered in neuroligin-deficient brains and cultured neurons. Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts.
Free Keywords:ALPHA-NEUREXINS; EXCITATORY SYNAPSES; INHIBITORY SYNAPSES; BETA-NEUREXINS; CA2+ CHANNELS; AUTISM; PSD-95; BINDING; PROTEIN; RECEPTORS
External Publication Status:published
Document Type:Article
Communicated by:Nils Brose
Affiliations:MPI für experimentelle Medizin/Molecular neurobiology
Relations:Has References-DOI:10.1016/j.neuron.2006.09.003
Identifiers:ISSN:0896-6273 [ID No:1]
ISI:000240997900013 [ID No:2]
ISI:000240997900013 [ID No:3]
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