MPI für molekulare Genetik / Department of Vertebrate Genomics |
|Construction and Analysis of a Human-Chimpanzee Comparative Clone Map|
|Authors:||Fujiyama, Asao; Watanabe, Hidemi; Toyoda, Atsushi; Taylor, Todd D.; Itoh, Takehiko; Tsai, Shih-Feng; Park, Hong-Seog; Yaspo, Marie-Laure; Lehrach, Hans; Chen, Zhu; Fu, Gang; Saitou, Naruya; Osoegawa, Kazutoyo; de Jong, Pieter J.; Suto, Yumiko; Hattori, Masahira; Sakaki, Yoshiyuki|
|Date of Publication (YYYY-MM-DD):||2002|
|Title of Journal:||Science|
|Issue / Number:||5552|
|Copyright:||The American Association for the Advancement of Science.|
|Review Status:||not specified|
|Abstract / Description:||The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.|
|External Publication Status:||published|
|Communicated by:||Hans Lehrach|
|Affiliations:||MPI für molekulare Genetik|
|External Affiliations:||RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411-8450, Japan.
Mitsubishi Research Institute, 3-6, Otemachi 2-chome Chiyoda-ku, Tokyo 100-8141, Japan.
National Yang-Ming University, 128, Yen-chiu, Yuan Road, Sec. 2, Taipei 115, Taiwan.
National Health Research Institutes, 128, Yen-chiu, Yuan Road, Sec. 2, Taipei 115, Taiwan.
Genome Research Center, KRIBB, 52 Oun-dong, Yusong-gu, Daejeon 305-333, Korea.
Chinese National Human Genome Center at Shanghai, 351, Guo Shou Jing Road, Shanghai 201203, China.
Children's Hospital Oakland Research Institute, BACPAC Resources, 747 52nd Street, Oakland, CA 94609-1809, USA.
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongou, Bunkyou-ku, Tokyo 113-0033, Japan.
Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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