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          Institute: MPI für experimentelle Medizin     Collection: Neurogenetics     Display Documents



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ID: 292173.0, MPI für experimentelle Medizin / Neurogenetics
Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination
Authors:Benninger, Yves; Colognato, Holly; Thurnherr, Tina; Franklin, Robin J. M.; Leone, Dino P.; Atanasoski, Suzana; Nave, Klaus-Armin; ffrench-Constant, Charles; Suter, Ueli; Relvas, Joao B.
Language:English
Date of Publication (YYYY-MM-DD):2006-07
Title of Journal:Journal of Neuroscience
Journal Abbrev.:J. Neurosci.
Volume:26
Issue / Number:29
Start Page:7665
End Page:7673
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Previous reports, including transplantation experiments using dominant-negative inhibition of beta 1-integrin signaling in oligodendrocyte progenitor cells, suggested that beta 1-integrin signaling is required for myelination. Here, we test this hypothesis using conditional ablation of the beta 1-integrin gene in oligodendroglial cells during the development of the CNS. This approach allowed us to study oligodendroglial beta 1-integrin signaling in the physiological environment of the CNS, circumventing the potential drawbacks of a dominant-negative approach. We found that beta 1-integrin signaling has a much more limited role than previously expected. Although it was involved in stage-specific oligodendrocyte cell survival, beta 1-integrin signaling was not required for axon ensheathment and myelination per se. We also found that, in the spinal cord, remyelination occurred normally in the absence of beta 1-integrin. We conclude that, although beta 1-integrin may still contribute to other aspects of oligodendrocyte biology, it is not essential for myelination and remyelination in the CNS.
Free Keywords:integrins; oligodendrocytes; survival; myelin; remyelination; CNS MULTIPLE-SCLEROSIS; EXTRACELLULAR-MATRIX; ADHESION MOLECULE; CELL-ADHESION; IN-VITRO; INTEGRINS; EXPRESSION; DIFFERENTIATION; PROLIFERATION; DISRUPTION
External Publication Status:published
Document Type:Article
Communicated by:Klaus-Armin Nave
Affiliations:MPI für experimentelle Medizin/Neurogenetics
Relations:Has References-DOI:10.1523/JNEUROSCI.0444-06.2006
Identifiers:ISSN:0270-6474 [ID No:1]
ISI:000239359900015 [ID No:2]
ISI:000239359900015 [ID No:3]
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