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          Institute: MPI für experimentelle Medizin     Collection: Clinical Neuroscience     Display Documents



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ID: 292201.0, MPI für experimentelle Medizin / Clinical Neuroscience
Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin
Authors:Sirén, Anna-Leena; Radyushkin, Konstantin; Boretius, Susann; Kämmer, Daniel; Riechers, Claas-Christian; Natt, Oliver; Sargin, Derya; Watanabe, Takashi; Sperling, Swetlana; Michaelis, Thomas; Price, Jack; Meyer, Barbara; Frahm, Jens; Ehrenreich, Hannelore
Language:English
Date of Publication (YYYY-MM-DD):2006-02
Title of Journal:Brain
Journal Abbrev.:Brain
Volume:129
Start Page:480
End Page:489
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:In humans, neurotrauma is suspected to cause brain atrophy and accelerate slowly progressive neurodegenerative disorders, such as Alzheimer's disease or schizophrenia. However, a direct link between brain injury and subsequent delayed global neurodegeneration has remained elusive. Here we show that juvenile (4-week-old) mice that are given a discrete unilateral lesion of the parietal cortex, develop to adulthood without obvious clinical symptoms. However, when monitored 3 and 9 months after lesioning, using high-resolution three-dimensional MRI and behavioural testing, the same mice display global neurodegenerative changes. Surprisingly, erythropoietin, a haematopoietic growth factor with potent neuroprotective activity, prevents behavioural abnormalities, cognitive dysfunction and brain atrophy when given for 2 weeks after acute brain injury. This demonstrates that a localized brain lesion is a primary cause of delayed global neurodegeneration that can be efficiently counteracted by neuroprotection.
Free Keywords:EPO; MRI; neuroprotection; neurodegeneration; neurotrauma; schizophrenia DENTATE GYRUS; IN-VIVO; HIPPOCAMPAL NEUROGENESIS; CEREBRAL-ISCHEMIA; HEAD-INJURY; RAT; ADULT; SCHIZOPHRENIA; MICE; DYSFUNCTION
External Publication Status:published
Document Type:Article
Communicated by:Hannelore Ehrenreich
Affiliations:MPI für experimentelle Medizin/Clinical neuroscience
Relations:Has References-DOI:10.1093/brain/awh703
Identifiers:ISSN:0006-8950 [ID No:1]
ISI:000234965500019 [ID No:2]
ISI:000234965500019 [ID No:3]
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