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          Institute: MPI für experimentelle Medizin     Collection: Clinical Neuroscience     Display Documents



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ID: 292222.0, MPI für experimentelle Medizin / Clinical Neuroscience
Arginine challenge unravels persistent disturbances of urea cycle and gluconeogenesis in abstinent alcoholics
Authors:Hasselblatt, Martin; Krampe, Henning; Jacobs, Silke; Sindram, Heike; Armstrong, Victor W.; Hecker, Markus; Ehrenreich, Hannelore
Language:English
Date of Publication (YYYY-MM-DD):2006
Title of Journal:Alcohol and Alcoholism
Journal Abbrev.:Alcohol Alcohol
Volume:41
Issue / Number:4
Start Page:372
End Page:378
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Aims: Data on recovery from hormonal and metabolic sequelae of alcoholism in strictly controlled alcohol abstinence are mainly restricted to short-term abstention. Our previous findings of persistently decreased plasma and urinary urea concentrations in long-term abstinent alcoholics prompted us to further elucidate this unexplained phenomenon. Methods: The response of circulating urea cycle metabolites and glucose-regulating hormones to an intravenous load (30 g) of arginine hydrochloride was investigated in abstinent male alcoholics (n = 14) after complete recovery of all routine liver parameters and compared with that in healthy male controls (n = 15). Results: The arginine challenge provoked (i) higher peak concentrations of arginine and increased arginine/ornithine and ornithine/citrulline ratios in the plasma of abstinent alcoholics; (ii) augmented plasma glutamine concentrations in alcoholics in the presence of comparable levels in both experimental groups of plasma glutamate, ammonia, and nitrate/nitrite; (iii) parallel increases in plasma urea concentrations over the respective baseline levels but distinctly higher urinary urea excretion in controls; (iv) a blunted blood glucose response to arginine in alcoholics together with a reduced insulin and glucagon surge; and (v) an elevated growth hormone peak as compared with controls. Conclusions: Application of an intravenous arginine challenge reveals profound and lasting metabolic and hormonal disturbances in abstinent alcoholics, affecting urea cycle and gluconeogenesis. The common denominator of many of these changes may be an acquired irreversible deficiency in cellular energy regulation.
Free Keywords:GROWTH-HORMONE; RAT-LIVER; INSULIN-SECRETION; PLASMA-LEVELS; VASOPRESSIN; ETHANOL; MITOCHONDRIA; HEPATOCYTES; ENZYMES; STIMULATION
External Publication Status:published
Document Type:Article
Communicated by:Hannelore Ehrenreich
Affiliations:MPI für experimentelle Medizin/Clinical neuroscience
Identifiers:ISSN:0735-0414 [ID No:1]
ISI:000238759300005 [ID No:2]
ISI:000238759300005 [ID No:3]
DOI:10.1093/alcalc/ag1032
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