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          Institute: MPI für Dynamik komplexer technischer Systeme     Collection: Systems and Control Theory     Display Documents



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ID: 293479.1, MPI für Dynamik komplexer technischer Systeme / Systems and Control Theory
Optimal Operation of Enantioseparation by Batch-Wise Preferential Crystallization
Authors:Angelov, I.; Raisch, J.; Elsner, M. P.; Seidel-Morgenstern, A.
Language:English
Date of Publication (YYYY-MM-DD):2008
Title of Journal:Chemical Engineering Science
Volume:63
Issue / Number:5 - Special Issue for Control of Particulate Processes VII
Start Page:1282
End Page:1292
Review Status:not specified
Audience:Experts Only
Abstract / Description:This article describes batch-wise preferential crystallization separation of mixtures of L- and D- threonine. Use of online polarimetry combined with refractometry and microscopic investigation of the solid phase provides information on the crystallization kinetics. Results obtained for different crystallization conditions (supersaturation, temperature and enantiomeric excess) in a batch crystallizer are presented. Based on these results, a nonlinear dynamic model has been developed. The control problem is to determine an optimal temperature profile which will result in a maximum amount of product with required quality. In this dynamic optimization problem B-splines have been used for interpolation of the temperature profile.

Copyright © 2007 Elsevier Ltd All rights reserved.
[accessed June 6, 2008]
Free Keywords:Preferential crystallization; Batch-wise non-isothermal crystallization; Dynamic optimization; B-spline interpolation
External Publication Status:published
Document Type:Article
Communicated by:Jörg Raisch
Affiliations:MPI für Dynamik komplexer technischer Systeme/Systems and Control Theory
MPI für Dynamik komplexer technischer Systeme/Physical and Chemical Foundations of Process Engineering
External Affiliations:Technical University Berlin

Otto-von-Guericke University Magdeburg
Identifiers:LOCALID:7/08
URL:http://dx.doi.org/10.1016/j.ces.2007.07.023
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