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          Institute: MPI für Infektionsbiologie     Collection: Department of Molecular Biology     Display Documents

ID: 300487.0, MPI für Infektionsbiologie / Department of Molecular Biology
Sex and virulence in Escherichia coli: an evolutionary perspective
Authors:Wirth, Thierry; Falush, Daniel; Lan, Ruiting; Colles, Frances; Mensa, Patience; Wieler, Lothar H.; Karch, Helge; Reeves, Peter R.; Maiden, Martin C. J.; Ochman, Howard; Achtman, Mark
Date of Publication (YYYY-MM-DD):2006-06
Title of Journal:Molecular Microbiology
Journal Abbrev.:Mol. Microbiol.
Issue / Number:5
Start Page:1136
End Page:1151
Copyright:© 2006 The Authors
Review Status:Peer-review
Audience:Experts Only
Abstract / Description:Pathogenic Escherichia coli cause over 160 million cases of dysentery and one million deaths per year, whereas non-pathogenic E. coli constitute part of the normal intestinal flora of healthy mammals and birds. The evolutionary pathways underlying this dichotomy in bacterial lifestyle were investigated by multilocus sequence typing of a global collection of isolates. Specific pathogen types [enterohaemorrhagic E. coli, enteropathogenic E. coli, enteroinvasive E. coli, K1 and Shigella] have arisen independently and repeatedly in several lineages, whereas other lineages contain only few pathogens. Rates of evolution have accelerated in pathogenic lineages, culminating in highly virulent organisms whose genomic contents are altered frequently by increased rates of homologous recombination; thus, the evolution of virulence is linked to bacterial sex. This long-term pattern of evolution was observed in genes distributed throughout the genome, and thereby is the likely result of episodic selection for strains that can escape the host immune response.
External Publication Status:published
Document Type:Article
Communicated by:Hilmar Fünning
Affiliations:MPI für Infektionsbiologie/Department of Molecular Biology
External Affiliations:Univ Konstanz, Dept Biol, Lehrstuhl Zool & Evolutionsbiol, D-78457 Constance, Germany.; Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia.; Univ Oxford, Oxford OX1 3SY, England.; Free Univ Berlin, Inst Mikrobiol & Tierseuchen, D-10115 Berlin, Germany.; Univ Munster, Inst Hyg, D-48149 Munster, Germany.; Univ Sydney, Sch Mol & Microbial Biosci, Sydney, NSW 2006, Australia.; Univ Arizona, Dept Biochem & Mol Biophys, Tucson, AZ 85721 USA.
Identifiers:ISI:000237423300006 [ID No:1]
ISSN:0950-382X [ID No:2]
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