Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 1 - Protein Evolution (A. Lupas)     Display Documents



  history
ID: 305786.0, MPI für Entwicklungsbiologie / Abteilung 1 - Protein Evolution (A. Lupas)
Common evolutionary origin of swapped-hairpin and double-psi beta barrels.
Authors:Coles, Murray; Hulko, Michael; Djuranovic, Sergej; Truffault, Vincent; Koretke, Kristin; Martin, Jörg; Lupas, Andrei
Language:English
Date of Publication (YYYY-MM-DD):2006-10
Title of Journal:Structure
Volume:14
Issue / Number:(10)
Start Page:1489
End Page:1498
Sequence Number of Article:17027498
Review Status:not specified
Audience:Not Specified
Abstract / Description:The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 1 - Proteinevolution (Andrei Lupas)
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.