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          Institute: MPI für Entwicklungsbiologie     Collection: Abteilung 1 - Protein Evolution (A. Lupas)     Display Documents



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ID: 305907.0, MPI für Entwicklungsbiologie / Abteilung 1 - Protein Evolution (A. Lupas)
Trimeric autotransporter adhesins: variable structure, common function.
Authors:Linke, Dirk; Riess, T.; Authenrieth, Ingo; Lupas, Andrei; Kempf, V. A. J.
Language:English
Date of Publication (YYYY-MM-DD):2006-06
Title of Journal:Trends Microbiol. 2006 Jun;14(6):264-70.
Volume:14
Issue / Number:6
Start Page:264
End Page:270
Sequence Number of Article:16678419
Review Status:not specified
Audience:Not Specified
Abstract / Description:Trimeric autotransporter adhesins (TAAs) are important virulence factors in gram-negative pathogens. Despite the variety of hosts ranging from plants to mammals and the specialized regulation of TAAs, their molecular organization follows surprisingly simple rules: they form trimeric surface structures with a head-stalk-anchor architecture. The head and stalk are composed of a small set of domains, building blocks that are frequently arranged repetitively. We propose that this repetitive arrangement facilitates recombination of domains to modulate the specificity of the common function: adhesion to the host.
External Publication Status:published
Document Type:Article
Affiliations:MPI für Entwicklungsbiologie/Abteilung 1 - Proteinevolution (Andrei Lupas)
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