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          Institute: MPI für medizinische Forschung     Collection: Abteilung Molekulare Neurobiologie     Display Documents



ID: 307544.0, MPI für medizinische Forschung / Abteilung Molekulare Neurobiologie
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases
Translation of Title:Modulation of microRNA processing and expression through RNA editing by ADAR deaminases
Authors:Yang, Weidong; Chendrimada, Thimmaiah; Wang, Qingde; Higuchi, Miyoko; Seeburg, Peter H.; Shiekhattar, Ramin; Nishikura, Kazuko
Language:English
Date of Publication (YYYY-MM-DD):2006-12-20
Title of Journal:Nature Structural and Molecular Biology
Journal Abbrev.:Nat. Struct. Mol. Biol.
Volume:13
Issue / Number:1
Start Page:13
End Page:21
Review Status:Peer-review
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Adenosine deaminases acting on RNA (ADARs) are involved in editing of adenosine residues to inosine in double−stranded RNA (dsRNA). Although this editing recodes and alters functions of several mammalian genes, its most common targets are noncoding repeat sequences, indicating the involvement of this editing system in currently unknown functions other than recoding of protein sequences. Here we show that specific adenosine residues of certain microRNA (miRNA) precursors are edited by ADAR1 and ADAR2. Editing of pri−miR−142 was degraded by Tudor−SN, a component of RISC and also a ribonuclease specific to inosine−containing dsRNAs. Consequently, mature miRNA−142 expression levels increased substantially in ADAR1 null or ADAR2 null mice. Our results demonstrate a new function of RNA editing in the control of miRNA biogenesis.
Last Change of the Resource (YYYY-MM-DD):--
External Publication Status:published
Document Type:Article
Communicated by:Wulf Kaiser
Affiliations:MPI für medizinische Forschung/Abteilung Molekulare Neurobiologie
Identifiers:LOCALID:6648
URI:http://www.nature.com/nsmb/journal/v13/n1/pdf/nsmb...
URI:http://www.nature.com/nsmb/journal/v13/n1/full/nsm...
URI:http://www.nature.com/nsmb/journal/v13/n1/abs/nsmb...
DOI:10.1038/nsmb1041
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