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          Institute: MPI für molekulare Genetik     Collection: Department of Human Molecular Genetics     Display Documents



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ID: 307708.0, MPI für molekulare Genetik / Department of Human Molecular Genetics
Platelet-derived serotonin mediates liver regeneration
Authors:Lesurtel, Mickael; Graf, Rolf; Aleil, Boris; Walther, Diego J.; Tian, Yinghua; Jochum, Wolfram; Gachet, Christian; Bader, Michael; Clavien, Pierre-Alain
Language:English
Date of Publication (YYYY-MM-DD):2006-04-07
Title of Journal:Science
Journal Abbrev.:Scie
Volume:312
Issue / Number:5770
Start Page:104
End Page:107
Copyright:© 2006 American Association for the Advancement of Science. All Rights Reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration.
Comment of the Author/Creator:To whom correspondence should be addressed. E-mail: clavien@chir.unizh.ch
External Publication Status:published
Document Type:Article
Communicated by:Hans-Hilger Ropers
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland;
2.Department of Pathology, University Hospital of Zurich, Switzerland;
3.Institut National de la Santé et de la Recherche Médicale 311, Etablissement Français du Sang-Alsace, Strasbourg, France,
4.Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Identifiers:ISSN:0036-8075
DOI:10.1126/science.1123842
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