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          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents



ID: 309552.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
Family specific rates of protein evolution
Authors:Luz, Hannes; Vingron, Martin
Language:English
Date of Publication (YYYY-MM-DD):2006-03-01
Title of Journal:Bioinformatics
Journal Abbrev.:2
Volume:10
Start Page:1166
End Page:1171
Copyright:© 2007 Oxford University Press
Review Status:not specified
Audience:Experts Only
Abstract / Description:Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins.
Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.
Comment of the Author/Creator:Contact: luz@molgen.mpg.de

Supplementary information: http://speeds.molgen.mpg.de
External Publication Status:published
Document Type:Article
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
Identifiers:ISSN:1367-4803
DOI:10.1093/bioinformatics/btl073
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