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          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents



ID: 309737.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
About the interrelation of evolutionary rate and protein age
Authors:Luz, Hannes; Staub, Eike; Vingron, Martin
Language:English
Date of Publication (YYYY-MM-DD):2006-01-01
Title of Journal:Genome Informatics : Japanese Society for Bioinformatics
Volume (in Journal):17
Issue / Number:1
Full Name of Issue-Editor(s):C. DeLisi, M. Kanehisa, R. Heinrich and S. Miyano
Start Page:240
End Page:250
Name of Conference/Meeting:Sixth International Workshop on Bioinformatics and Systems Biology
Place of Conference/Meeting:Boston University, USA
(Start) Date of Conference/Meeting
 (YYYY-MM-DD):
2006-07-24
End Date of Conference/Meeting 
 (YYYY-MM-DD):
2006-07-26
Review Status:not specified
Audience:Experts Only
Abstract / Description:Evolutionary rate and gene age are interrelated when the age of a gene is assessed by the taxonomic
distribution in the gene family. This is because homology detection by sequence comparison
is depending on sequence similarity. We estimate family specific rates of protein evolution for orthologous
families with representatives from man, fugu, fly, and worm. In fact, we observe that
younger proteins tend to evolve faster than older ones. We estimate time points of duplication
events that gave rise to novel protein functions and show that younger proteins were duplicated
more recently than older ones.
Free Keywords:protein evolution, evolutionary rates, gene age, gene duplication
External Publication Status:published
Document Type:Conference-Paper
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
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