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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2006     Display Documents



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ID: 311103.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2006
Mechanically induced actin-mediated rocketing of phagosomes
Authors:Clarke, Margaret; Muller-Taubenberger, Annette; Anderson, Kurt I; Engel, Ulrike; Gerisch, Gunther
Date of Publication (YYYY-MM-DD):2006
Title of Journal:Molecular Biology of the Cell
Volume:17
Issue / Number:11
Start Page:4866
End Page:4875
Copyright:not available
Review Status:not specified
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Actin polymerization can be induced in Dictyostelium by compressing the cells to bring phagosomes filled with large particles into contact with the plasma membrane. Asymmetric actin assembly results in rocketing movement of the phagosomes. We show that the compression-induced assembly of actin at the cytoplasmic face of the plasma membrane involves the Arp2/3 complex. We also identify two other proteins associated with the mechanically induced actin assembly. The class I myosin MyoB accumulates at the plasma membrane-phagosome interface early during the initiation of the response, and coronin is recruited as the actin filaments are disassembling. The forces generated by rocketing phagosomes are sufficient to push the entire microtubule apparatus forward and to dislocate the nucleus.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:789
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