Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2006     Display Documents



ID: 311131.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2006
Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels
Authors:Yu, Jun; Bergaya, Sonia; Murata, Takahisa; Alp, Ilkay F; Bauer, Michael P; Lin, Michelle I; Drab, Marek; Kurzchalia, Teymuras V; Stan, Radu V; Sessa, William C
Date of Publication (YYYY-MM-DD):2006
Title of Journal:Journal of Clinical Investigation
Volume:116
Issue / Number:5
Start Page:1284
End Page:1291
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Caveolae in endothelial cells have been implicated as plasma membrane microdomains that sense or transduce hemodynamic changes into biochemical signals that regulate vascular function. Therefore we compared long- and short-term flow-mediated mechanotransduction in vessels from WT mice, caveolin-1 knockout (Cav-1 KO) mice, and Cav-1 KO mice reconstituted with a transgene expressing Cav-1 specifically in endothelial cells (Cav-1 RC mice). Arterial remodeling during chronic changes in flow and shear stress were initially examined in these mice. Ligation of the left external carotid for 14 days to lower blood flow in the common carotid artery reduced the lumen diameter of carotid arteries from WT and Cav-1 RC mice. In Cav-1 KO mice, the decrease in blood flow did not reduce the lumen diameter but paradoxically increased wall thickness and cellular proliferation. In addition, in isolated pressurized carotid arteries, flow-mediated dilation was markedly reduced in Cav-1 KO arteries compared with those of WT mice. This impairment in response to flow was rescued by reconstituting Cav-1 into the endothelium. In conclusion, these results showed that endothelial Cav-1 and caveolae are necessary for both rapid and long-term mechanotransduction in intact blood vessels.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:800
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.