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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2006     Display Documents



ID: 311137.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2006
Molecular biology: chromosome guardians on duty
Authors:Riedel, Christian G.; Katis, Vittorio L.; Katou, Yuki; Mori, Saori; Itoh, Takehiko; Helmhart, Wolfgang; Galova, Marta; Petronczki, Mark; Gregan, Juraj; Cetin, Bulent; Mudrak, Ingrid; Ogris, Egon; Mechtler, Karl; Pelletier, Laurence; Buchholz, Frank; Shirahige, Katsuhiko; Nasmyth, Kim
Date of Publication (YYYY-MM-DD):2006
Title of Journal:Nature
Volume:441
Issue / Number:7089
Start Page:35
End Page:37
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arms due to proteolytic cleavage of cohesin's Rec8 subunit by separase resolves chiasmata and thereby triggers the first meiotic division. This produces univalent chromosomes, the chromatids of which are held together by centromeric cohesin that has been protected from separase by shugoshin (Sgo1/MEI-S332) proteins. Here we show in both fission and budding yeast that Sgo1 recruits to centromeres a specific form of protein phosphatase 2A (PP2A). Its inactivation causes loss of centromeric cohesin at anaphase I and random segregation of sister centromeres at the second meiotic division. Artificial recruitment of PP2A to chromosome arms prevents Rec8 phosphorylation and hinders resolution of chiasmata. Our data are consistent with the notion that efficient cleavage of Rec8 requires phosphorylation of cohesin and that this is blocked by PP2A at meiosis I centromeres.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:746
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