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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2006     Display Documents



ID: 311138.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2006
Minimizing the risk of reporting false positives in large-scale RNAi screens
Authors:Echeverri, Christophe J; Beachy, Philip A; Baum, Buzz; Boutros, Michael; Buchholz, Frank; Chanda, Sumit K; Downward, Julian; Ellenberg, Jan; Fraser, Andrew G; Hacohen, Nir; Hahn, William C; Jackson, Aimee L; Kiger, Amy; Linsley, Peter S; Lum, Lawrence; Ma, Yong; Mathey-Prevot, Bernard; Root, David E; Sabatini, David M; Taipale, Jussi; Perrimon, Norbert; Bernards, Rene
Date of Publication (YYYY-MM-DD):2006
Title of Journal:Nature Methods
Volume:3
Issue / Number:10
Start Page:777
End Page:779
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Large-scale RNA interference (RNAi)-based analyses, very much as other 'omic' approaches, have inherent rates of false positives and negatives. The variability in the standards of care applied to validate results from these studies, if left unchecked, could eventually begin to undermine the credibility of RNAi as a powerful functional approach. This Commentary is an invitation to an open discussion started among various users of RNAi to set forth accepted standards that would insure the quality and accuracy of information in the large datasets coming out of genome-scale screens.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:745
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