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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2006     Display Documents



ID: 311142.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2006
Centriole assembly in Caenorhabditis elegans
Authors:Pelletier, Laurence; O'Toole, Eileen; Schwager, Anne; Hyman, Anthony A; Muller-Reichert, Thomas
Date of Publication (YYYY-MM-DD):2006
Title of Journal:Nature
Volume:444
Issue / Number:7119
Start Page:619
End Page:623
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Centrioles are necessary for flagella and cilia formation, cytokinesis, cell-cycle control and centrosome organization/spindle assembly. They duplicate once per cell cycle, but the mechanisms underlying their duplication remain unclear. Here we show using electron tomography of staged C. elegans one-cell embryos that daughter centriole assembly begins with the formation and elongation of a central tube followed by the peripheral assembly of nine singlet microtubules. Tube formation and elongation is dependent on the SAS-5 and SAS-6 proteins, whereas the assembly of singlet microtubules onto the central tube depends on SAS-4. We further show that centriole assembly is triggered by an upstream signal mediated by SPD-2 and ZYG-1. These results define a structural pathway for the assembly of a daughter centriole and should have general relevance for future studies on centriole assembly in other organisms.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:737
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