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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2006     Display Documents



ID: 311207.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2006
The vascular basement membrane: a niche for insulin gene expression and beta cell proliferation
Authors:Nikolova, Ganka; Jabs, Normund; Konstantinova, Irena; Domogatskaya, Anna; Tryggvason, Karl; Sorokin, Lydia; Fässler, Reinhard; Gu, Guoqiang; Gerber, Hans-Peter; al., Napoleone Ferrara et
Date of Publication (YYYY-MM-DD):2006
Title of Journal:Developmental Cell
Volume:10
Issue / Number:3
Start Page:397
End Page:405
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:Endocrine pancreatic beta cells require endothelial signals for their differentiation and function. However, the molecular basis for such signals remains unknown. Here we show that beta cells, in contrast to the exocrine pancreatic cells, do not form a basement membrane. Instead, by using VEGF-A, they attract endothelial cells, which form capillaries with a vascular basement membrane next to the beta cells. We have identified laminins, among other vascular basement membrane proteins, as endothelial signals, which promote insulin gene expression and proliferation in beta cells. We further demonstrate that ?1-integrin is required for the beta cell response to the laminins. The proposed mechanism explains why beta cells must interact with endothelial cells, and it may apply to other cellular processes in which endothelial signals are required.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
Identifiers:LOCALID:660
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