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          Institute: MPI für molekulare Zellbiologie und Genetik     Collection: Publikationen MPI-CBG 2006     Display Documents

ID: 311210.0, MPI für molekulare Zellbiologie und Genetik / Publikationen MPI-CBG 2006
Monopolar attachment of sister kinetochores at Meiosos I Requires Casein Kinase 1
Authors:Petroncki, Mark; Matos, Joao; Mori, Saori; Gregan, Juraj; Bogdanova, Aliona; Schwickart, Martin; Mechtler, Karl; Shirahige, Katsuhiko; Zachariae, Wolfgang; Nasmyth, Kim
Date of Publication (YYYY-MM-DD):2006
Title of Journal:Cell
Issue / Number:6
Start Page:1049
End Page:1064
Copyright:not available
Audience:Experts Only
Intended Educational Use:No
Abstract / Description:In meiosis, a single round of DNA replication is followed by two consecutive rounds of chromosome segregation, called meiosis I and II. Disjunction of maternal from paternal centromeres during meiosis I depends on the attachment of sister kinetochores to microtubules emanating from the same pole. In budding yeast, monopolar attachment requires recruitment to kinetochores of the monopolin complex. How monopolin promotes monopolar attachment was unclear, as its subunits are poorly conserved and lack similarities to proteins with known functions. We show here that the monopolin subunit Mam1 binds tightly to Hrr25, a highly conserved casein kinase 1 δ/var epsilon (CK1δ/var epsilon), and recruits it to meiosis I centromeres. Hrr25 kinase activity and Mam1 binding are both essential for monopolar attachment. Since CK1δ/var epsilon activity is important for accurate chromosome segregation during meiosis I also in fission yeast, phosphorylation of kinetochore proteins by CK1δ/var epsilon might be an evolutionary conserved process required for monopolar attachment.
External Publication Status:published
Document Type:Article
Communicated by:N. N.
Affiliations:MPI für molekulare Zellbiologie und Genetik
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