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          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents



ID: 311384.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome
Authors:Qin, Yan; Polacek, Norbert; Vesper, Oliver; Staub, Eike; Einfeldt, Edda; Wilson, Daniel N.; Nierhaus, Knud
Language:English
Date of Publication (YYYY-MM-DD):2006-11-17
Title of Journal:Cell
Journal Abbrev.:Cell
Volume:127
Issue / Number:4
Start Page:721
End Page:733
Copyright:Copyright © 2007 Elsevier B.V. All rights reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:The ribosomal elongation cycle describes a series of reactions prolonging the nascent polypeptide chain by one amino acid and driven by two universal elongation factors termed EF-Tu and EF-G in bacteria. Here we demonstrate that the extremely conserved LepA protein, present in all bacteria and mitochondria, is a third elongation factor required for accurate and efficient protein synthesis. LepA has the unique function of back-translocating posttranslocational ribosomes, and the results suggest that it recognizes ribosomes after a defective translocation reaction and induces a back-translocation, thus giving EF-G a second chance to translocate the tRNAs correctly. We suggest renaming LepA as elongation factor 4 (EF4).
Comment of the Author/Creator:Corresponding author : Knud Nierhaus
External Publication Status:published
Document Type:Article
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Division of Genomics and RNomics, Innsbruck Medical University, Biocenter, 6020 Innsbruck, Austria.
Identifiers:ISSN:0092-8674
DOI:10.1016/j.cell.2006.09.037
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