Please note that eDoc will be permanently shut down in the first quarter of 2021!      Home News About Us Contact Contributors Disclaimer Privacy Policy Help FAQ

Home
Search
Quick Search
Advanced
Fulltext
Browse
Collections
Persons
My eDoc
Session History
Login
Name:
Password:
Documentation
Help
Support Wiki
Direct access to
document ID:


          Institute: MPI für molekulare Genetik     Collection: Department of Computational Molecular Biology     Display Documents



ID: 311384.0, MPI für molekulare Genetik / Department of Computational Molecular Biology
The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome
Authors:Qin, Yan; Polacek, Norbert; Vesper, Oliver; Staub, Eike; Einfeldt, Edda; Wilson, Daniel N.; Nierhaus, Knud
Language:English
Date of Publication (YYYY-MM-DD):2006-11-17
Title of Journal:Cell
Journal Abbrev.:Cell
Volume:127
Issue / Number:4
Start Page:721
End Page:733
Copyright:Copyright © 2007 Elsevier B.V. All rights reserved.
Review Status:not specified
Audience:Experts Only
Abstract / Description:The ribosomal elongation cycle describes a series of reactions prolonging the nascent polypeptide chain by one amino acid and driven by two universal elongation factors termed EF-Tu and EF-G in bacteria. Here we demonstrate that the extremely conserved LepA protein, present in all bacteria and mitochondria, is a third elongation factor required for accurate and efficient protein synthesis. LepA has the unique function of back-translocating posttranslocational ribosomes, and the results suggest that it recognizes ribosomes after a defective translocation reaction and induces a back-translocation, thus giving EF-G a second chance to translocate the tRNAs correctly. We suggest renaming LepA as elongation factor 4 (EF4).
Comment of the Author/Creator:Corresponding author : Knud Nierhaus
External Publication Status:published
Document Type:Article
Communicated by:Martin Vingron
Affiliations:MPI für molekulare Genetik
External Affiliations:1.Division of Genomics and RNomics, Innsbruck Medical University, Biocenter, 6020 Innsbruck, Austria.
Identifiers:ISSN:0092-8674
DOI:10.1016/j.cell.2006.09.037
Full Text:
Sorry, no privileges
The scope and number of records on eDoc is subject to the collection policies defined by each institute - see "info" button in the collection browse view.