MPI für biologische Kybernetik / Biologische Kybernetik |
|Network-based de-noising improves prediction from microarray data|
|Authors:||Kato, T.; Murata, Y.; Miura, K.; Asai, K.; Horton, P.B.; Tsuda, K.; Fujibuchi, W.|
|Date of Publication (YYYY-MM-DD):||2006-03|
|Title of Journal:||BMC Bioinformatics|
|Issue / Number:||Suppl. 1|
|Intended Educational Use:||No|
|Abstract / Description:||Prediction of human cell response to anti-cancer drugs (compounds) from microarray data is a challenging problem, due to the noise properties of microarrays as well as the high variance of living cell responses to drugs. Hence there is a strong need for more practical and robust methods than standard methods for real-value prediction. We devised an extended version of the off-subspace noise-reduction (de-noising) method to incorporate heterogeneous network data such as sequence similarity or protein-protein interactions into a single framework. Using that method, we first de-noise the gene expression data for training and test data and also the drug-response data for training data. Then we predict the unknown responses of each drug from the de-noised input data. For ascertaining whether de-noising improves prediction or not, we carry out 12-fold cross-validation for assessment of the prediction performance. We use the Pearson‘s correlation coefficient between the true and predicted respon|
se values as the prediction performance. De-noising improves the prediction performance for 65% of drugs. Furthermore, we found that this noise reduction method is robust and effective even when a large amount of artificial noise is added to the
input data. We found that our extended off-subspace noise-reduction method combining heterogeneous biological data is successful and quite useful to improve prediction of human cell cancer drug responses from microarray data.
|External Publication Status:||published|
|Communicated by:||Holger Fischer|
|Affiliations:||MPI für biologische Kybernetik/Empirical Inference (Dept. Schölkopf)|
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